Ordering Your Tests

Please click here for information on ordering the HILOmet tests. A completed and signed Requisition Form by your clinician is required. Click here for the Requisition Form. Two specimen collection options are available for your convenience

Option 1: Blood Draw (For Connecticut residents only)
  • Have your clinician fill out and sign the requisition form.
  • Take the completed requisition form to a Clinical Laboratory Partners location. No appointment is necessary. A copy of the insurance card should be included.
  • Clinical Laboratory Partners will draw your blood and deliver it to the Laboratory of Personalized Health.
Option 2: Buccal (cheek) swab
  • Your clinician should request a buccal swab kit from the Laboratory of Personalized Health.
  • Either the clinician or you should swab the insides of your cheeks.
  • Your clinician should fill out and sign the included requisition form. Please include a copy of the insurance card.
  • Mail the swab and forms via U.S. Postal Service.

How can the HILOmet PhyzioType System help me?

The HILOmet System is designed to provide clinicians with an unprecedented capability to select for each patient the safest and most effective drug to achieve treatment goals and enhance patient compliance. This personalized medicine allows optimal selection and dosing of a drug for you among the existing pharmaceutical options for your condition. Importantly, personalized medicine does not mean that a special chemical compound will be made or prepared just for you.

What kinds of medication can be therapeutically guided by the system?

The HILOmet PhyzioType System is for DNA-Guided neuro-psychiatric and cardio-metabolic drug management. Clinicians refer patients for evaluation of innate drug metabolism for 250 medications: 130 neuro-psychiatric drugs (antidepressants, neuroleptics, anticonvulsants, anxiolytics, stimulants, analgesics, hypnotics) and 120 cardio-metabolic drugs (to treat hypertension, diabetes, angina, thrombosis, gastro-esophageal reflux disease, erectile dysfunction, asthma).

How many tests are required for the HILOmet System?

The HILOmet system requires 3 gene tests to be performed: CYP2C9, CYP2C19, CYP2D6. By having these 3 genes analyzed, your innate drug metabolism capacity can be established and compared against the specific requirements of a given drug. In effect, the HILOmet System and the Personalized Health Portal, can "route" a drug selection and assign a dose to those medications that the individual patient can best process.

Could only one test be performed?

When only one drug is being prescribed, and that drug requires a specific metabolic demand, a single test may be relevant. For example, when the clinical question is whether a patient can activate the drug clopidogrel (Plavix®) or the cancer drug tamoxifen (Nolvadex®), it could be appropriate to order, respectively, the CYP2C19 or CYP2D6 test. However, many patients are on multiple medications requiring metabolism in aggregate by the 3 enzymes, and several medications require 2 or 3 of the enzymes as well. The situation is analogous to a traffic report. HILOmet provides an assessment of the highway system capacity, by incorporating the lane availability and vehicle load on each of 3 major highways. A single highway report does not offer information on other routes available, and cannot characterize the transport system.

What samples are needed for the HILOmet tests, and are there any fasting requirements prior to collection?

The patient sample can be a buccal cheek swab or a blood sample. Genomas will provide your clinician with a special plastic foam swab to collect the sample from your mouth lining. There is no need to fast or provide the sample at any specific time of the day. DNA is stable in life and does not change in the body (except for tumors and for transplanted organs).

Who can order the HILOmet tests?

Any health care provider with drug prescription privileges can order these tests for you. The HILOmet and ThromboNet Systems are clinical laboratory services, and not available for direct-to-consumer sale.

What is the ThromboNet system, and how is it different from HILOmet?

The ThromboNet System enables diagnosis and management of complications related to blood clotting [venous thrombo-embolism (VTE), deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI)] and folate. Factor II (Prothrombin) and Factor V (Leiden) are involved in blood coagulation. Patients with thrombosis are treated with oral anti-coagulant ("blood thinning") medications [warfarin (Coumadin®), dabigatran (Predaxa®), rivaroxaban (Xarelto®)]. Vitamin K Epoxide Reductase subunit 1 (VKORC1) is inhibited by warfarin, to exert the drug's anticoagulant effect. Patients with Methylenetetrahydrofolate Reductase (MTHFR) deficiency may be treated with folate supplementation.

Does my insurance cover the cost of the HILOmet tests?

In 2012, public and private insurance payers consistently covered the HILOmet tests in many diagnoses (for example, adverse drug reactions, therapeutic management, pain control, cardiovascular management, and treatment of mental illness). Effective 2013, the entire industry of molecular diagnostics ("gene testing"), including Genomas, has undergone a total overhaul of the insurance codes (termed "CPT") used for billing these tests. As a result, while the new codes are implemented, there may be discordance between an insurer's payments for the Genomas tests in 2012 versus now. Your insurance may cover the HILOmet tests, or you may choose a simple self-pay option or Financial Assistance Plan offered by Genomas. In all insurance, there is the key consideration of contractual deductibles, which vary widely among policies but are the patient's responsibility. For more information on all these particulars, please click here or contact our Customer Support Specialist (TEL 860-972-4574, Email LPH@genomas.net). We will gladly assist with any questions and support you.